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A novel ß-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
Tanton, Helen; Sewastianik, Tomasz; Seo, Hyuk-Soo; Remillard, David; Pierre, Roodolph St; Bala, Pratyusha; Aitymbayev, Daulet; Dennis, Peter; Adler, Keith; Geffken, Ezekiel; Yeoh, Zoe; Vangos, Nicholas; Garbicz, Filip; Scott, David; Sethi, Nilay; Bradner, James; Dhe-Paganon, Sirano; Carrasco, Ruben D.
Afiliação
  • Tanton H; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Sewastianik T; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Seo HS; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine,, Warsaw, Poland.
  • Remillard D; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Pierre RS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Bala P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Aitymbayev D; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Dennis P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Adler K; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Geffken E; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Yeoh Z; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Vangos N; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Garbicz F; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Scott D; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Sethi N; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Bradner J; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Dhe-Paganon S; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Carrasco RD; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine,, Warsaw, Poland.
Sci Adv ; 8(17): eabm3108, 2022 04 29.
Article em En | MEDLINE | ID: mdl-35486727
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Beta Catenina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Beta Catenina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article