Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.

Batson, Bethany D; Zorn, Bryan T; Radicioni, Giorgia; Livengood, Stephanie S; Kumagai, Tadahiro; Dang, Hong; Ceppe, Agathe; Clapp, Phillip W; Tunney, Michael; Elborn, J Stuart; McElvaney, Noel G; Muhlebach, Marianne S; Boucher, Richard C; Tiemeyer, Michael; Wolfgang, Matthew C; Kesimer, Mehmet

Batson, Bethany D; Zorn, Bryan T; Radicioni, Giorgia; Livengood, Stephanie S; Kumagai, Tadahiro; Dang, Hong; Ceppe, Agathe; Clapp, Phillip W; Tunney, Michael; Elborn, J Stuart; McElvaney, Noel G; Muhlebach, Marianne S; Boucher, Richard C; Tiemeyer, Michael; Wolfgang, Matthew C; Kesimer, Mehmet.

Afiliação

Batson BD; Marsico Lung Institute/Cystic Fibrosis Research Center.
Zorn BT; Department of Pathology and Laboratory Medicine.
Radicioni G; Marsico Lung Institute/Cystic Fibrosis Research Center.
Livengood SS; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kumagai T; Marsico Lung Institute/Cystic Fibrosis Research Center.
Dang H; Department of Pathology and Laboratory Medicine.
Ceppe A; Marsico Lung Institute/Cystic Fibrosis Research Center.
Clapp PW; Department of Pathology and Laboratory Medicine.
Tunney M; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia.
Elborn JS; Marsico Lung Institute/Cystic Fibrosis Research Center.
McElvaney NG; Marsico Lung Institute/Cystic Fibrosis Research Center.
Muhlebach MS; Marsico Lung Institute/Cystic Fibrosis Research Center.
Boucher RC; Queen's University, Belfast, Northern Ireland, United Kingdom; and.
Tiemeyer M; Queen's University, Belfast, Northern Ireland, United Kingdom; and.
Wolfgang MC; Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
Kesimer M; Marsico Lung Institute/Cystic Fibrosis Research Center.

Am J Respir Cell Mol Biol ; 67(2): 253-265, 2022 08.

Article em En | MEDLINE | ID: mdl-35486871

Assuntos

Fibrose Cística; Fibrose Cística/patologia; Humanos; Inflamação; Mucina-5AC; Mucina-5B; Muco; Proteômica; Sistema Respiratório/patologia

Palavras-chave

cystic fibrosis; inflammation; microbiome; mucins; mucus obstruction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Cística Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google