ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.

Zhong, Xiaodan; Wang, Tao; Zhang, Wenjun; Wang, Mengwen; Xie, Yang; Dai, Lei; He, Xingwei; Madhusudhan, Thati; Zeng, Hesong; Wang, Hongjie

Zhong, Xiaodan; Wang, Tao; Zhang, Wenjun; Wang, Mengwen; Xie, Yang; Dai, Lei; He, Xingwei; Madhusudhan, Thati; Zeng, Hesong; Wang, Hongjie.

Afiliação

Zhong X; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
Wang T; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Department of Cardiology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, PR China.
Zhang W; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
Wang M; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
Xie Y; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
Dai L; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
He X; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China.
Madhusudhan T; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.
Zeng H; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China. Electronic address: zenghs@tjh.tjmu.edu.cn.
Wang H; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China. Electronic address: hongjie.wang@tjh.tjmu.edu.cn.

J Biol Chem ; 298(6): 101989, 2022 06.

Article em En | MEDLINE | ID: mdl-35490780

Assuntos

Cisteína Endopeptidases/metabolismo; Diabetes Mellitus Experimental; Cardiomiopatias Diabéticas; Fatores de Transcrição/metabolismo; Animais; Enzimas Desubiquitinantes/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Glucose; Camundongos; Fosforilação; Proteínas Quinases S6 Ribossômicas 90-kDa/metabolismo

Palavras-chave

OTU deubiquitinase; Y-box binding protein-1; diabetic cardiomyopathy; extracellular signal-regulated kinase; p90 ribosomal S6 kinase; ubiquitin aldehyde binding 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Cisteína Endopeptidases / Diabetes Mellitus Experimental / Cardiomiopatias Diabéticas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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