Low molecular weight glycerol derived coatings on magnetic nanoparticles: role of initiator, temperature, rate of monomer addition, enhanced biocompatibility and stability.
RSC Adv
; 11(63): 40140-40147, 2021 Dec 13.
Article
em En
| MEDLINE
| ID: mdl-35494117
ABSTRACT
Biocompatible polymer coatings for magnetic nanoparticles have shown to drastically increase their usability towards biomedical applications. The coatings imprint characteristics such as stability, resistance to non-specific adsorption and tolerance in complex media for biomedicine. Herein, a thorough investigation towards the anionic ring-opening polymerization of glycidol on the surface of carbon-coated cobalt nanoparticle was performed. Reaction parameters that influence polymer growth have been investigated. Thereafter, a maximal achievable hyperbranched polyglycidol M w of up to 1148 g mol-1 under optimal reaction conditions was obtained. With this coating, the dispersion stability of the particles could be substantially increased, the non-specific adsorption of proteins could be decreased to 10% while retaining an efficient magnetic separation.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article