Saucerneol attenuates nasopharyngeal carcinoma cells proliferation and metastasis through selectively targeting Grp94.

Cheng, Yanfang; Wang, Qian; Zhang, Zhikang; Zhao, Chao; Zhou, Huihao; Xu, Jun; Gu, Qiong

Cheng, Yanfang; Wang, Qian; Zhang, Zhikang; Zhao, Chao; Zhou, Huihao; Xu, Jun; Gu, Qiong.

Afiliação

Cheng Y; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Wang Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhang Z; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhao C; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: ttzc123@163.com.
Zhou H; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: guqiong@mail.sysu.edu.cn.

Phytomedicine ; 101: 154133, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35504052

Assuntos

Furanos/farmacologia; Proteínas de Choque Térmico HSP70/metabolismo; Lignanas/farmacologia; Proteínas de Membrana/metabolismo; Neoplasias Nasofaríngeas; Fosfatidilinositol 3-Quinases; Animais; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos; Camundongos Nus; Carcinoma Nasofaríngeo/metabolismo; Neoplasias Nasofaríngeas/tratamento farmacológico; Neoplasias Nasofaríngeas/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Grp94; Hsp90; Nasopharyngeal carcinoma; PI3K/AKT/mTOR; Saucerneol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Lignanas / Proteínas de Choque Térmico HSP70 / Fosfatidilinositol 3-Quinases / Furanos / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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