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Omics-guided metabolic pathway discovery in plants: Resources, approaches, and opportunities.
Zhao, Kangmei; Rhee, Seung Y.
Afiliação
  • Zhao K; Carnegie Institution for Science, Department of Plant Biology, Stanford, CA, USA. Electronic address: kzhao@carnegiescience.edu.
  • Rhee SY; Carnegie Institution for Science, Department of Plant Biology, Stanford, CA, USA.
Curr Opin Plant Biol ; 67: 102222, 2022 06.
Article em En | MEDLINE | ID: mdl-35512431
ABSTRACT
Plants produce a vast array of metabolites, the biosynthetic routes of which remain largely undetermined. Genome-scale enzyme and pathway annotations and omics technologies have revolutionized research to decrypt plant metabolism and produced a growing list of functionally characterized metabolic genes and pathways. However, what is known is still a tiny fraction of the metabolic capacity harbored by plants. Here, we review plant enzyme and pathway annotation resources and cutting-edge omics approaches to guide discovery and characterization of plant metabolic pathways. We also discuss strategies for improving enzyme function prediction by integrating protein 3D structure information and single cell omics. This review aims to serve as a primer for plant biologists to leverage omics datasets to facilitate understanding and engineering plant metabolism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas / Redes e Vias Metabólicas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas / Redes e Vias Metabólicas Idioma: En Ano de publicação: 2022 Tipo de documento: Article