Pharmacological assessment of Ru(II) complex with GidA protein- A novel topoisomerase II inhibitor towards cancer therapeutics.

Infanta S, Antony K Teresa; Durairaju, Nisshanthini; Raja, Senthil; Murugesan, Thandeeswaran; Dhanapal, Anand Raj; Natarajan, Karupannan; Balakrishnan, Ajithkumar; Vedagiri, Hemamalini; Muthusamy, Palaniswamy; Jayaraman, Angayarkanni

Infanta S, Antony K Teresa; Durairaju, Nisshanthini; Raja, Senthil; Murugesan, Thandeeswaran; Dhanapal, Anand Raj; Natarajan, Karupannan; Balakrishnan, Ajithkumar; Vedagiri, Hemamalini; Muthusamy, Palaniswamy; Jayaraman, Angayarkanni.

Afiliação

Infanta S AKT; Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Durairaju N; Department of Biotechnology, New Prince Shri Bhavani Arts and Science College, Chennai, Tamil Nadu, India.
Raja S; Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Murugesan T; Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.
Dhanapal AR; Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Natarajan K; Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.
Balakrishnan A; Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.
Vedagiri H; Molecular Genomics Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India.
Muthusamy P; Molecular Genomics Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India.
Jayaraman A; Department of Microbiology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

J Biomol Struct Dyn ; 41(9): 4143-4153, 2023 06.

Article em En | MEDLINE | ID: mdl-35514135

Assuntos

Neoplasias; Rutênio; Humanos; Inibidores da Topoisomerase II/farmacologia; Simulação de Acoplamento Molecular; Proteína Estafilocócica A; Rutênio/farmacologia; Rutênio/química; Neoplasias/tratamento farmacológico; DNA Topoisomerases Tipo II/metabolismo

Palavras-chave

CD spectroscopy; GidA protein; Ruthenium(II) complexes; UV-absorption spectroscopy; fluorescence quenching

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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