An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1'-(arylmethylene)diurea.
RSC Adv
; 10(50): 30062-30068, 2020 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-35518255
ABSTRACT
An efficient method for the synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one by using 1,1'-(arylmethylene)diurea and 1-aryl-2-propanone as substrates was developed. The reactions proceeded efficiently in the presence of Cs2CO3 to give the desired products in moderate to good yields with wide substrate scope and good functional group tolerance, serving as an attractive alternative or complement to the previously reported methods for the facile assembly of biologically and pharmaceutically active 3,4-dihydropyrimidin-2(1H)-ones.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article