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The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS.
Tong, Y; Orang'o, E; Nakalembe, M; Tonui, P; Itsura, P; Muthoka, K; Titus, M; Kiptoo, S; Mwangi, A; Ong'echa, J; Tonui, R; Odongo, B; Mpamani, C; Rosen, B; Moormann, A; Cu-Uvin, S; Bailey, J A; Oduor, C I; Ermel, A; Yiannoutsos, C; Musick, B; Sang, E; Ngeresa, A; Banturaki, G; Kiragga, A; Zhang, J; Song, Y; Chintala, S; Katzenellenbogen, R; Loehrer, P; Brown, D R.
Afiliação
  • Tong Y; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Orang'o E; Moi University, Eldoret, Kenya.
  • Nakalembe M; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Tonui P; Moi University, Eldoret, Kenya.
  • Itsura P; Moi University, Eldoret, Kenya.
  • Muthoka K; Moi University, Eldoret, Kenya.
  • Titus M; Maseno University, Kisumu, Kenya.
  • Kiptoo S; Moi University, Eldoret, Kenya.
  • Mwangi A; Moi University, Eldoret, Kenya.
  • Ong'echa J; Kenya Medical Research Institute, Eldoret, Kenya.
  • Tonui R; Moi University, Eldoret, Kenya.
  • Odongo B; Moi University, Eldoret, Kenya.
  • Mpamani C; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Rosen B; Beaumont Gynecology Oncology, Royal Oak, MI, USA.
  • Moormann A; University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Cu-Uvin S; Brown University, Providence, RI, USA.
  • Bailey JA; Brown University, Providence, RI, USA.
  • Oduor CI; Brown University, Providence, RI, USA.
  • Ermel A; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Yiannoutsos C; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Musick B; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Sang E; AMPATH, Eldoret, Kenya.
  • Ngeresa A; AMPATH, Eldoret, Kenya.
  • Banturaki G; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Kiragga A; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Zhang J; Indiana University Fairbanks School of Public Health, Indianapolis, IN, USA.
  • Song Y; Indiana University Fairbanks School of Public Health, Indianapolis, IN, USA.
  • Chintala S; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Katzenellenbogen R; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Loehrer P; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Brown DR; Indiana University School of Medicine, Indianapolis, IN, USA.
Ann Med ; 54(1): 1202-1211, 2022 12.
Article em En | MEDLINE | ID: mdl-35521812
ABSTRACT
The East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer, and to encourage collaborations between researchers in North America and East African countries. To date, studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on the persistence of HPV, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP. It will now be determined how HPV testing fits into cervical cancer screening programs in Kenya and Uganda, how aflatoxin influences immunological control of HIV, how HPV alters certain genes involved in the growth of tumours in HIV-infected women. Although there have been challenges in performing this research, with time, this work should help to reduce the burden of cervical cancer and other cancers related to HIV infection in people living in sub-Saharan Africa, as well as optimized processes to better facilitate research as well as patient autonomy and safety. KEY MESSAGESThe East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer.Collaborations have been established between researchers in North America and East African countries for these studies.Studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on HPV detection, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Aflatoxinas / Infecções por Papillomavirus / Alphapapillomavirus Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Aflatoxinas / Infecções por Papillomavirus / Alphapapillomavirus Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article