The extracellular matrix and immunity: breaking the old barrier in cancer.

Vyas, Maulik; Demehri, Shadmehr

Vyas, Maulik; Demehri, Shadmehr.

Afiliação

Vyas M; Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Demehri S; Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: sdemehri1@mgh.harvard.edu.

Trends Immunol ; 43(6): 423-425, 2022 06.

Article em En | MEDLINE | ID: mdl-35527181

ABSTRACT

ABSTRACT

Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies highlight ECM as an active regulator of immunity in cancer.

Assuntos

Matriz Extracelular; Neoplasias; Colágeno; Receptor com Domínio Discoidina 1; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Matriz Extracelular / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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