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Graphene nanoplatelets-sericin surface-modified Gum alloy for improved biological response.
Mitran, Valentina; Dinca, Valentina; Ion, Raluca; Cojocaru, Vasile D; Neacsu, Patricia; Dinu, Cerasela Zoica; Rusen, Laurentiu; Brajnicov, Simona; Bonciu, Anca; Dinescu, Maria; Raducanu, Doina; Dan, Ioan; Cimpean, Anisoara.
Afiliação
  • Mitran V; University of Bucharest, Department of Biochemistry and Molecular Biology 91-95 Spl. Independentei 050095 Bucharest Romania anisoara.cimpean@bio.unibuc.ro rciubar@yahoo.com +40 21 3181575/102 +40 21 3181575/106.
  • Dinca V; National Institute for Lasers, Plasma and Radiation Physics 409 Atomistilor Street, Magurele 077125 Romania.
  • Ion R; University of Bucharest, Department of Biochemistry and Molecular Biology 91-95 Spl. Independentei 050095 Bucharest Romania anisoara.cimpean@bio.unibuc.ro rciubar@yahoo.com +40 21 3181575/102 +40 21 3181575/106.
  • Cojocaru VD; University POLITEHNICA of Bucharest 313 Spl. Independentei 060042 Bucharest Romania.
  • Neacsu P; University of Bucharest, Department of Biochemistry and Molecular Biology 91-95 Spl. Independentei 050095 Bucharest Romania anisoara.cimpean@bio.unibuc.ro rciubar@yahoo.com +40 21 3181575/102 +40 21 3181575/106.
  • Dinu CZ; West Virginia University, Department of Chemical and Biomedical Engineering Morgantown West Virginia 26506 USA.
  • Rusen L; National Institute for Lasers, Plasma and Radiation Physics 409 Atomistilor Street, Magurele 077125 Romania.
  • Brajnicov S; National Institute for Lasers, Plasma and Radiation Physics 409 Atomistilor Street, Magurele 077125 Romania.
  • Bonciu A; University of Craiova, Faculty of Mathematics and Natural Science 13 Alexandru Ioan Cuza 200585 Craiova Romania.
  • Dinescu M; National Institute for Lasers, Plasma and Radiation Physics 409 Atomistilor Street, Magurele 077125 Romania.
  • Raducanu D; University of Bucharest, Faculty of Physics 405 Atomistilor, Magurele 077125 Romania.
  • Dan I; National Institute for Lasers, Plasma and Radiation Physics 409 Atomistilor Street, Magurele 077125 Romania.
  • Cimpean A; University POLITEHNICA of Bucharest 313 Spl. Independentei 060042 Bucharest Romania.
RSC Adv ; 8(33): 18492-18501, 2018 May 17.
Article em En | MEDLINE | ID: mdl-35541109
In this study a "Gum Metal" titanium-based alloy, Ti-31.7Nb-6.21Zr-1.4Fe-0.16O, was synthesized by melting and characterized in order to evaluate its potential for biomedical applications. The results showed that the newly developed alloy presents a very high strength, high plasticity and a low Young's modulus relative to titanium alloys currently used in medicine. For further bone implant applications, the newly synthesized alloy was surface modified with graphene nanoplatelets (GNP), sericin (SS) and graphene nanoplatelets/sericine (GNP-SS) composite films via Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The characterization of each specimen was monitored by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle (CA) measurements, and Fourier Transform Infrared Spectroscopy (FTIR). The materials' surface analyses suggested the successful coating of GNP, SS and GNP-SS onto the alloy surface. Additionally, the activities of pre-osteoblasts such as cell adhesion, cytoskeleton organization, cell proliferation and differentiation potentials exhibited on these substrates were investigated. Results showed that the GNP-SS-coated substrate significantly enhanced the growth and osteogenic differentiation of MC3T3-E1 cells when compared to bare and GNP-coated alloy. Collectively, the results show that GNP-SS surface-modified Gum alloy can modulate the bioactivity of the pre-osteoblasts holding promise for improved biological response in vivo.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article