Total Synthesis of Sarpagine Alkaloid (-)-Normacusine B.
Org Lett
; 24(19): 3515-3520, 2022 05 20.
Article
em En
| MEDLINE
| ID: mdl-35544733
ABSTRACT
An asymmetric total synthesis of the sarpagine alkaloid (-)-normacusine B is presented. Salient features of this synthesis include a photocatalytic nitrogen-centered radical cascade reaction to assemble the tetrahydrocarbolinone skeleton, a titanium-mediated intramolecular amide-alkene coupling to construct the bridged azabicyclo[3.3.1]nonane moiety, and a nickel-catalyzed reductive Heck coupling to assemble the azabicyclo[2.2.2]octane ring system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcaloides Indólicos
/
Alcaloides
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article