Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome.

Gorris, Mark A J; van der Woude, Lieke L; Kroeze, Leonie I; Bol, Kalijn; Verrijp, Kiek; Amir, Avital L; Meek, Jelena; Textor, Johannes; Figdor, Carl G; de Vries, I Jolanda M

Gorris, Mark A J; van der Woude, Lieke L; Kroeze, Leonie I; Bol, Kalijn; Verrijp, Kiek; Amir, Avital L; Meek, Jelena; Textor, Johannes; Figdor, Carl G; de Vries, I Jolanda M.

Afiliação

Gorris MAJ; Tumor Immunology, Radboudumc, Nijmegen, The Netherlands.
van der Woude LL; Oncode Institute, Nijmegen, The Netherlands.
Kroeze LI; Tumor Immunology, Radboudumc, Nijmegen, The Netherlands.
Bol K; Oncode Institute, Nijmegen, The Netherlands.
Verrijp K; Pathology, Radboudumc, Nijmegen, The Netherlands.
Amir AL; Pathology, Radboudumc, Nijmegen, The Netherlands.
Meek J; Medical Oncology, Radboudumc, Nijmegen, The Netherlands.
Textor J; Oncode Institute, Nijmegen, The Netherlands.
Figdor CG; Pathology, Radboudumc, Nijmegen, The Netherlands.
de Vries IJM; Pathology, Radboudumc, Nijmegen, The Netherlands.

J Immunother Cancer ; 10(5)2022 05.

Article em En | MEDLINE | ID: mdl-35550553

Assuntos

Melanoma; Biomarcadores Tumorais/metabolismo; Humanos; Ipilimumab/uso terapêutico; Linfócitos do Interstício Tumoral; Melanoma/tratamento farmacológico; Melanoma/genética; Microambiente Tumoral

Palavras-chave

Immunohistochemistry; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Melanoma; Tumor Microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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