Examination of the Impact of CYP3A4/5 on Drug-Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.

He, Qingfeng; Bu, Fengjiao; Wang, Qizhen; Li, Min; Lin, Jiaying; Tang, Zhijia; Mak, Wen Yao; Zhuang, Xiaomei; Zhu, Xiao; Lin, Hai-Shu; Xiang, Xiaoqiang

He, Qingfeng; Bu, Fengjiao; Wang, Qizhen; Li, Min; Lin, Jiaying; Tang, Zhijia; Mak, Wen Yao; Zhuang, Xiaomei; Zhu, Xiao; Lin, Hai-Shu; Xiang, Xiaoqiang.

Afiliação

He Q; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Bu F; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Wang Q; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Li M; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Lin J; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Tang Z; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Mak WY; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Zhuang X; Clinical Research Centre, Hospital Pulau Pinang, Pinang 10450, Malaysia.
Zhu X; Institute for Clinical Research, National Institute of Health, Shah Alam 40170, Malaysia.
Lin HS; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Xiang X; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.

Int J Mol Sci ; 23(9)2022 Apr 19.

Article em En | MEDLINE | ID: mdl-35562875

Assuntos

Citocromo P-450 CYP3A; Tacrolimo; Ciclo-Octanos; Citocromo P-450 CYP3A/metabolismo; Sistema Enzimático do Citocromo P-450; Dioxóis; Interações Medicamentosas; Humanos; Imunossupressores/farmacocinética; Lignanas; Modelos Biológicos; Compostos Policíclicos; Tacrolimo/farmacocinética

Palavras-chave

CYP3A5 polymorphism; Wuzhi capsule (WZC); drugdrug interaction (DDI); physiologically based pharmacokinetic (PBPK); schizandrol A (SZA); schizandrol B (SZB); tacrolimus (FK-506)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tacrolimo / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google