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Synthetic Pyrethroids Exposure and Embryological Outcomes: A Cohort Study in Women from Fertility Clinic.
Radwan, Pawel; Wielgomas, Bartosz; Radwan, Michal; Krasinski, Rafal; Kilanowicz-Sapota, Anna; Banaszczyk, Renata; Jurewicz, Joanna.
Afiliação
  • Radwan P; Gameta Health Centre, 7 Cybernetyki St., 02-677 Warsaw, Poland.
  • Wielgomas B; Gameta, Kielce-Regional Science-Technology Centre, 45 Podzamcze St., Checiny, 26-060 Kielce, Poland.
  • Radwan M; Department of Toxicology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland.
  • Krasinski R; Department of Gynecology and Reproduction, Gameta Hospital, 34/36 Rudzka St., 95-030 Rzgow, Poland.
  • Kilanowicz-Sapota A; Faculty of Health Sciences, Mazovian State University in Plock, 2 Dabrowskiego Sq., 09-402 Plock, Poland.
  • Banaszczyk R; Department of Gynecology and Reproduction, Gameta Hospital, 34/36 Rudzka St., 95-030 Rzgow, Poland.
  • Jurewicz J; Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Article em En | MEDLINE | ID: mdl-35564520
ABSTRACT
Pyrethroids exposure has been associated with adverse reproductive outcome. However, there is no study that explores the effect of environmental exposure and embryological outcomes. This question was addressed in a prospective cohort of couples undergoing fertility treatment. The study aims to assess the association between urinary metabolites of synthetic pyrethroids and embryological outcomes (MII oocyte count, top quality embryo, fertilization and implantation rate). We included 450 women aged 25−45 undergoing assisted reproductive technology (ART) cycle at Infertility Clinic in Poland. Urine samples were collected at the time of fertility procedure(s) to assess four urinary synthetic pyrethroids concentrations (3-phenoxybenzoic acid (3PBA), cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA), cis-2,2-dibromovinyl-2,2-dimethylocyclopropane-1-carboxylic acid (DBCA)) using validated gas chromatography ion-tap mass spectrometry and calculated for each cycle-specific metabolite. To evaluate the effect of environmental exposure to synthetic pyrethroids and embryological outcomes (methaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate), multivariable generalized linear mixed analyses with random intercepts were prepared. Urinary 3-PBA concentrations decrease MII oocyte count (p = 0.007) in the fourth quartile (>75 percentile) compared to women in the first quartile (≤25 percentile). Additionally, when 3-PBA was treated as continuous variable, the negative association between exposure to pyrethroids and MII oocyte count was also observed (p = 0.012). Exposure to other pyrethroid metabolities (CDCCA, TDCCA, DBCA) was not related to any of the examined embryological outcomes. Exposure to synthetic pyrethroids may be associated with poorer embryological outcome among couples seeking fertility treatments. As this is the first study on this topic, the results need to be confirmed in further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piretrinas / Inseticidas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piretrinas / Inseticidas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article