The Glutaminase Inhibitor Compound 968 Exhibits Potent <i>In vitro</i> and <i>In vivo</i> Anti-tumor Effects in Endometrial Cancer.

Guo, Hui; Li, Wanhu; Pan, Guoyou; Wang, Cong; Li, Dapeng; Liu, Naifu; Sheng, Xiugui; Yuan, Lingqin

The Glutaminase Inhibitor Compound 968 Exhibits Potent In vitro and In vivo Anti-tumor Effects in Endometrial Cancer.

Guo, Hui; Li, Wanhu; Pan, Guoyou; Wang, Cong; Li, Dapeng; Liu, Naifu; Sheng, Xiugui; Yuan, Lingqin.

Afiliação

Guo H; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Li W; Department of Medical Imaging, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Pan G; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Wang C; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Li D; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Liu N; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Sheng X; National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Shenzhen, China.
Yuan L; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Anticancer Agents Med Chem ; 23(2): 210-221, 2023.

Article em En | MEDLINE | ID: mdl-35570522

Assuntos

Neoplasias do Endométrio; Glutaminase; Animais; Feminino; Humanos; Camundongos; Apoptose; Linhagem Celular Tumoral; Proliferação de Células; Neoplasias do Endométrio/tratamento farmacológico; Neoplasias do Endométrio/patologia; Glutaminase/antagonistas & inibidores; Glutamina/metabolismo; Paclitaxel/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR

Palavras-chave

Endometrial cancer; compound 968; glutaminase-1 enzyme (GLS1); glutamine; inhibitor; phospho-S6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Glutaminase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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