Recent progress in biologically active indole hybrids: a mini review.
Pharmacol Rep
; 74(4): 570-582, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-35594012
ABSTRACT
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and antibacterial properties. Scientists are therefore interested in the synthesis of biologically active indole-based hybrids such as indole-coumarin, indole-chalcone, indole-isatin, indole-pyrimidine and so on, with the aim of improving activity, selectivity, and mitigating side effects. This review will discuss the newly synthesized indole-based hybrids along with their biological activity which will be useful in drug discovery and development.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article