3,3'-Diindolylmethane attenuates inflammation and fibrosis in radiation-induced lung injury by regulating NF-&#954;B/TGF-ß/Smad signaling pathways.

Zhou, Xia; Bao, Wu-An; Zhu, Xiang; Lin, Juan; Fan, Ju-Fen; Yang, Yang; Du, Xiang-Hui; Wang, Yue-Zhen

3,3'-Diindolylmethane attenuates inflammation and fibrosis in radiation-induced lung injury by regulating NF-κB/TGF-ß/Smad signaling pathways.

Zhou, Xia; Bao, Wu-An; Zhu, Xiang; Lin, Juan; Fan, Ju-Fen; Yang, Yang; Du, Xiang-Hui; Wang, Yue-Zhen.

Afiliação

Zhou X; Department of Radiation Therapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang Province, China.
Bao WA; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province, China.
Zhu X; Department of Radiation Therapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang Province, China.
Lin J; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province, China.
Fan JF; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province, China.
Yang Y; Department of Radiation Therapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang Province, China.
Du XH; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province, China.
Wang YZ; Department of Radiation Therapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang Province, China.

Exp Lung Res ; 48(3): 103-113, 2022 04.

Article em En | MEDLINE | ID: mdl-35594367

Assuntos

Lesão Pulmonar; NF-kappa B; Animais; Fibrose; Indóis; Inflamação/tratamento farmacológico; Interleucina-6/metabolismo; Pulmão/metabolismo; Camundongos; NF-kappa B/metabolismo; RNA Mensageiro; Transdução de Sinais; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

3,3'-Diindolylmethane; NF-κB; TGFß/Smad pathway; inflammatory; pulmonary fibrosis; radiation-induced lung injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Lesão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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