Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles.

Bhome, Rahul; Emaduddin, Muhammad; James, Victoria; House, Louise M; Thirdborough, Stephen M; Mellone, Massimiliano; Tulkens, Joeri; Primrose, John N; Thomas, Gareth J; De Wever, Olivier; Mirnezami, Alex H; Sayan, A Emre

Bhome, Rahul; Emaduddin, Muhammad; James, Victoria; House, Louise M; Thirdborough, Stephen M; Mellone, Massimiliano; Tulkens, Joeri; Primrose, John N; Thomas, Gareth J; De Wever, Olivier; Mirnezami, Alex H; Sayan, A Emre.

Afiliação

Bhome R; Cancer Sciences Unit, University of Southampton, Southampton, UK.
Emaduddin M; University Surgery, University of Southampton, Southampton, UK.
James V; Cancer Sciences Unit, University of Southampton, Southampton, UK.
House LM; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Thirdborough SM; Cancer Sciences Unit, University of Southampton, Southampton, UK.
Mellone M; Cancer Sciences Unit, University of Southampton, Southampton, UK.
Tulkens J; Cancer Sciences Unit, University of Southampton, Southampton, UK.
Primrose JN; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Thomas GJ; University Surgery, University of Southampton, Southampton, UK.
De Wever O; Cancer Sciences Unit, University of Southampton, Southampton, UK.
Mirnezami AH; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Sayan AE; Cancer Sciences Unit, University of Southampton, Southampton, UK.

J Extracell Vesicles ; 11(5): e12226, 2022 05.

Article em En | MEDLINE | ID: mdl-35595718

Assuntos

Neoplasias Colorretais; Transição Epitelial-Mesenquimal; Vesículas Extracelulares; MicroRNAs; Animais; Neoplasias Colorretais/genética; Transição Epitelial-Mesenquimal/genética; Vesículas Extracelulares/genética; Vesículas Extracelulares/metabolismo; Fibroblastos/metabolismo; Humanos; Camundongos; MicroRNAs/genética; MicroRNAs/metabolismo; Fenótipo

Palavras-chave

MiR-200; Zeb1; cancer-associated fibroblast; colorectal cancer; epithelial to mesenchymal transition; extracellular vesicle; stroma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MicroRNAs / Transição Epitelial-Mesenquimal / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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