The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin.

Wang, Ruhua; Fu, Yunong; Yao, Menglin; Cui, Xiaomeng; Zhao, Yan; Lu, Xinlan; Li, Yarui; Lin, Yiguang; He, Shuixiang

Wang, Ruhua; Fu, Yunong; Yao, Menglin; Cui, Xiaomeng; Zhao, Yan; Lu, Xinlan; Li, Yarui; Lin, Yiguang; He, Shuixiang.

Afiliação

Wang R; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Fu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Yao M; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Cui X; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Zhao Y; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Lu X; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Li Y; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Lin Y; School of Life Sciences, University of Technology Sydney, Broadway, NSW, Australia.
He S; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, China.

FEBS J ; 289(20): 6400-6419, 2022 10.

Article em En | MEDLINE | ID: mdl-35596723

Assuntos

Carcinoma Hepatocelular; Proteína HMGB1; Neoplasias Hepáticas; Animais; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Regulação Neoplásica da Expressão Gênica; Proteína HMGB1/genética; Proteína HMGB1/metabolismo; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Metástase Neoplásica; Oxaliplatina/farmacologia; Proteína 28 com Motivo Tripartido/genética; Proteína 28 com Motivo Tripartido/metabolismo

Palavras-chave

HMGB1; HN1; cell proliferation; metastasis; oxaliplatin sensitivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Proteína HMGB1 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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