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Real-world long-term analysis of daclatasvir plus asunaprevir in patients with hepatitis C virus infection.
Fujii, Hideki; Kimura, Hiroyuki; Hasebe, Chitomi; Akahane, Takehiro; Satou, Takashi; Kusakabe, Atsunori; Kojima, Yuji; Kondo, Masahiko; Marusawa, Hiroyuki; Kobashi, Haruhiko; Tsuji, Keiji; Ogawa, Chikara; Uchida, Yasushi; Joko, Kouji; Mitsuda, Akeri; Kurosaki, Masayuki; Izumi, Namiki.
Afiliação
  • Fujii H; Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
  • Kimura H; Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
  • Hasebe C; Department of Gastroenterology Asahikawa Red Cross Hospital Asahikawa Japan.
  • Akahane T; Department of Gastroenterology Japanese Red Cross Ishinomaki Hospital Ishinomaki Japan.
  • Satou T; Department of Gastroenterology Nasu Red Cross Hospital Otawara Japan.
  • Kusakabe A; Department of Gastroenterology Nagoya Daini Red Cross Hospital Nagoya Japan.
  • Kojima Y; Department of Gastroenterology and Hepatology Ise Red Cross Hospital Ise Japan.
  • Kondo M; Department of Gastroenterology Otsu Red Cross Hospital Siga Japan.
  • Marusawa H; Department of Gastroenterology and Hepatology Osaka Red Cross Hospital Osaka Japan.
  • Kobashi H; Department of Hepatology Japanese Red Cross Okayama Hospital Okayama Japan.
  • Tsuji K; Department of Gastroenterology Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital Hiroshima Japan.
  • Ogawa C; Department of Gastroenterology and Hepatology Takamatsu Red Cross Hospital Takamatsu Japan.
  • Uchida Y; Department of Gastroenterology Matsue Red Cross Hospital Matsue Japan.
  • Joko K; Center for Liver and Biliary Diseases Matsuyama Red Cross Hospital Ehime Japan.
  • Mitsuda A; Department of Gastroenterology Japanese Red Cross Tottori Hospital Tottori Japan.
  • Kurosaki M; Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Musashino Japan.
  • Izumi N; Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Musashino Japan.
JGH Open ; 6(5): 344-352, 2022 May.
Article em En | MEDLINE | ID: mdl-35601120
ABSTRACT
Background and

Aim:

This study aimed to evaluate the long-term clinical course of patients achieving a sustained virologic response (SVR) with daclatasvir plus asunaprevir (DCV/ASV) therapy.

Methods:

A total of 911 patients who achieved SVR with DCV/ASV were assessed. To evaluate pretreatment factors contributing to hepatocellular carcinoma (HCC) after SVR, univariate and multivariate analyses were performed in all patients, in those with preexisting HCC, and in those without preexisting HCC. We selected a low-risk group of HCC cases after SVR. Finally, we evaluated liver function after achieving SVR.

Results:

In multivariable analyses, male sex, older age, patients with a history of HCC treatment, excess alcohol use, lower albumin, and low platelet count remained significant in the overall group; male sex and low albumin remained significant in patients with a history of HCC treatment; and male sex, older age, excess alcohol use, low platelet count, high alpha-fetoprotein (AFP), and high des-γ-carboxy prothrombin (DCP) remained significant in those without a history of HCC treatment. Patients who had not received treatment for HCC, females, those under 70 years of age, and those with platelet count ≥13 (×104/µL), AFP <6 ng/mL, and DCP <23 mAU/mL were at low risk of HCC. The process of liver function improvement was different according to the factors.

Conclusions:

The incidence rate of HCC, risk factors associated with HCC, group with very low risk of developing HCC, and the clinical course in a real-world long-term study were evaluated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article