Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC<sub>50</sub> Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model.

Saleh, Mohammed A A; Bloemberg, Julia S; Elassaiss-Schaap, Jeroen; de Lange, Elizabeth C M

Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC₅₀ Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model.

Saleh, Mohammed A A; Bloemberg, Julia S; Elassaiss-Schaap, Jeroen; de Lange, Elizabeth C M.

Afiliação

Saleh MAA; Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Bloemberg JS; Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Elassaiss-Schaap J; Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
de Lange ECM; PD-value B.V., Houten, The Netherlands.

Pharm Res ; 39(7): 1303-1319, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35606598

Assuntos

Doença de Alzheimer; Acetilcolinesterase; Idoso; Envelhecimento; Doença de Alzheimer/tratamento farmacológico; Secretases da Proteína Precursora do Amiloide; Encéfalo; Butirilcolinesterase; Inibidores da Colinesterase/farmacocinética; Humanos; Indanos/farmacocinética; Piperidinas/farmacocinética; Rivastigmina

Palavras-chave

Alzheimer's; aging; physiologically based pharmacokinetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google