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Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection.
Alonso, Carolyn D; Pollock, Nira R; Garey, Kevin W; Gonzales-Luna, Anne J; Williams, David N; Daugherty, Kaitlyn; Cuddemi, Christine; Villafuerte-Gálvez, Javier; White, Nicole C; Chen, Xinhua; Xu, Hua; Sprague, Rebecca; Barrett, Caitlin; Miller, Mark; Foussadier, Agnès; Lantz, Aude; Banz, Alice; Kelly, Ciarán P.
Afiliação
  • Alonso CD; Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Pollock NR; Harvard Medical School, Boston, Massachusetts, USA.
  • Garey KW; Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Gonzales-Luna AJ; Harvard Medical School, Boston, Massachusetts, USA.
  • Williams DN; Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Daugherty K; Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
  • Cuddemi C; Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
  • Villafuerte-Gálvez J; Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • White NC; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Chen X; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Xu H; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Sprague R; Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Barrett C; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Miller M; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Foussadier A; Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Lantz A; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Banz A; Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Kelly CP; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Clin Infect Dis ; 75(11): 2019-2022, 2022 11 30.
Article em En | MEDLINE | ID: mdl-35607815
ABSTRACT
Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Clostridioides difficile / Infecções por Clostridium Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Clostridioides difficile / Infecções por Clostridium Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article