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MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune checkpoint blockade therapy.
Wan, Jing-Lei; Wang, Biao; Wu, Mei-Lan; Li, Jie; Gong, Ruo-Mu; Song, Li-Na; Zhang, Han-Shuo; Zhu, Gui-Qi; Chen, Shi-Ping; Cai, Jia-Liang; Xing, Xiao-Xia; Wang, Ya-Dong; Yang, Yi; Cai, Cheng-Zhe; Huang, Run; Liu, Hua; Dai, Zhi.
Afiliação
  • Wan JL; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Wang B; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China; Department of Radiation Oncology, Zhongsha
  • Wu ML; Hub Asia Pacific, Sanofi China Ltd., Shanghai, 200040, PR China.
  • Li J; Research and Development Department, GeneX Health Co., Ltd., Beijing, 100195, PR China.
  • Gong RM; Hub Asia Pacific, Sanofi China Ltd., Shanghai, 200040, PR China.
  • Song LN; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Zhang HS; Research and Development Department, GeneX Health Co., Ltd., Beijing, 100195, PR China.
  • Zhu GQ; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Chen SP; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Cai JL; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Xing XX; Department of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
  • Wang YD; Research and Development Department, GeneX Health Co., Ltd., Beijing, 100195, PR China.
  • Yang Y; Department of Radiation Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, PR China.
  • Cai CZ; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
  • Huang R; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China.
  • Liu H; Department of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China.
  • Dai Z; Liver Cancer Institute, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China. Electronic address: dai.zhi@zs-hospital.sh
Cancer Lett ; 541: 215750, 2022 08 10.
Article em En | MEDLINE | ID: mdl-35609735
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Proteínas de Ligação a RNA / Carcinoma Hepatocelular / Antígeno B7-H1 / Inibidores de Checkpoint Imunológico / Neoplasias Hepáticas / Proteínas de Membrana / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Proteínas de Ligação a RNA / Carcinoma Hepatocelular / Antígeno B7-H1 / Inibidores de Checkpoint Imunológico / Neoplasias Hepáticas / Proteínas de Membrana / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article