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A fresh look at a neglected regulatory lineage: CD8+Foxp3+ Regulatory T cells.
Liston, Adrian; Aloulou, Meryem.
Afiliação
  • Liston A; Babraham Research Campus, The Babraham Institute, Cambridge CB22 3AT, United Kingdom. Electronic address: adrian.liston@babraham.ac.uk.
  • Aloulou M; Babraham Research Campus, The Babraham Institute, Cambridge CB22 3AT, United Kingdom; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR, Toulouse 5051, France. Electronic address: meryem.aloulou@babraham.ac.uk.
Immunol Lett ; 247: 22-26, 2022 07.
Article em En | MEDLINE | ID: mdl-35609830
CD4+Foxp3+ Regulatory T cells (Tregs) are essential for maintaining self-tolerance and are increasingly recognised to have important roles in tissue homeostasis and repair. In the CD8 compartment an analogous Foxp3+ population is present, which shares phenotypic aspects with the more common CD4+Foxp3+Treg population. While oft neglected for their low frequency, there is increasing evidence that these CD8+Foxp3+ cells are bona fide regulatory cells, with both shared and distinct characteristics from their CD4+ analogue. Here we focus on the evidence for a regulatory function of CD8+Foxp3+ cells, and the potential unique role this neglected lineage may play in immune homeostasis and disease prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Fatores de Transcrição Forkhead Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Fatores de Transcrição Forkhead Idioma: En Ano de publicação: 2022 Tipo de documento: Article