Integrated Network Discovery Using Multi-Proteomic Data.
Methods Mol Biol
; 2456: 173-183, 2022.
Article
em En
| MEDLINE
| ID: mdl-35612742
ABSTRACT
A fundamental goal of systems biology is to seek a better understanding of the cell's molecular mechanisms. Experimentalists most frequently rely upon reductionist methods to isolate and analyze discrete signaling compartments, including subcellular domains, organelles, and protein-protein interactions. Among the systems-biology community, there is a growing need to integrate multiple datasets to resolve complex cellular networks. In this chapter, we share our procedures for the discovery of integrated signaling networks, across multi-proteomic data. Demonstrating these procedures, we provide an integrated analysis of the cellular proteome and extracellular (secretome) of human glioma LN229.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteoma
/
Proteômica
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article