Accumulation of pTreg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis.

Wang, Weikan; Thomas, Rachel; Oh, Jiyoung; Su, Dong-Ming

Wang, Weikan; Thomas, Rachel; Oh, Jiyoung; Su, Dong-Ming.

Afiliação

Wang W; Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Thomas R; Alcon Research, LLC, Fort Worth, Texas, 76134, USA.
Oh J; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Su DM; Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Aging Cell ; 21(6): e13630, 2022 06.

Article em En | MEDLINE | ID: mdl-35615905

Assuntos

Encefalomielite Autoimune Experimental; Esclerose Múltipla; Animais; Sistema Nervoso Central; Modelos Animais de Doenças; Fatores de Transcrição Forkhead; Camundongos; Camundongos Endogâmicos C57BL; Linfócitos T Reguladores

Palavras-chave

aging; autoimmunity; negative selection; regulatory T cell generation; thymic atrophy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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