Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones.
Chem Biodivers
; 19(7): e202200326, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35621325
ABSTRACT
Antimicrobial and cytotoxic activities were tested for dried MeOH extracts of Hieracium calophyllum (CAL), H.â
coloriscapum (COL), H.â
pseudoschenkii (PSE), H.â
valdepilosum (VAL) and H.â
glabratum (GLA) herbs (flowering aerial parts), their 2 sesquiterpene lactones (SLs) 8-epiixerisamine A and crepiside E, and dried CH2 Cl2 extract of H.â
scheppigianum (SCH) herb. In microdilution test, extracts showed activity on all tested microorganisms (8 bacteria, 10 fungi). The best effect was exhibited by SCH and CAL on Salmonella Typhimurium (MIC=1.7-2.5â
mg/mL MBC=3.4-5.0â
mg/mL), and SCH and VAL on Candida albicans (MIC=2.5â
mg/mL MFC=5.0â
mg/mL). SLs showed notable effect on all tested fungi Aspergillus ochraceus, Penicillium funiculosum, C.â
albicans and C.â
krusei (MIC=0.15-0.4â
mg/mL MFC=0.3-0.8â
mg/mL). In MTT test, extracts inhibited growth of all tested cancer cells (HeLa, LS174 and A549), with the best effect on HeLa (IC50 =148.1â
µg/mL for SCH, and 152.3-303.2â
µg/mL for MeOH extracts); both SLs were active against HeLa cells (IC50 =46.2â
µg/mL for crepiside E and 103.8â
µg/mL for 8-epiixerisamine A). Extracts and SLs showed good safety profile on normal MRC-5 cells.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Asteraceae
/
Anti-Infecciosos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article