Paper-Based Substrate for a Surface-Enhanced Raman Spectroscopy Biosensing Platform-A Silver/Chitosan Nanocomposite Approach.
Biosensors (Basel)
; 12(5)2022 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-35624567
ABSTRACT
Paper is a popular platform material in all areas of sensor research due to its porosity, large surface area, and biodegradability, to name but a few. Many paper-based nanocomposites have been reported in the last decade as novel substrates for surface-enhanced Raman spectroscopy (SERS). However, there are still limiting factors, like the low density of hot spots or loss of wettability. Herein, we designed a process to fabricate a silver-chitosan nanocomposite layer on paper celluloses by a layer-by-layer method and pH-triggered chitosan assembly. Under microscopic observation, the resulting material showed a nanoporous structure, and silver nanoparticles were anchored evenly over the nanocomposite layer. In SERS measurement, the detection limit of 4-aminothiophenol was 5.13 ppb. Furthermore, its mechanical property and a strategy toward further biosensing approaches were investigated.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quitosana
/
Nanocompostos
/
Nanopartículas Metálicas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article