Homologous Recombination Repair in Biliary Tract Cancers: A Prime Target for PARP Inhibition?

Yin, Chao; Kulasekaran, Monika; Roy, Tina; Decker, Brennan; Alexander, Sonja; Margolis, Mathew; Jha, Reena C; Kupfer, Gary M; He, Aiwu R

Yin, Chao; Kulasekaran, Monika; Roy, Tina; Decker, Brennan; Alexander, Sonja; Margolis, Mathew; Jha, Reena C; Kupfer, Gary M; He, Aiwu R.

Afiliação

Yin C; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
Kulasekaran M; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
Roy T; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
Decker B; Foundation Medicine, Cambridge, MA 20007, USA.
Alexander S; Foundation Medicine, Cambridge, MA 20007, USA.
Margolis M; Foundation Medicine, Cambridge, MA 20007, USA.
Jha RC; Department of Radiology, Georgetown University Medical Center, Washington, DC 20007, USA.
Kupfer GM; Departments of Oncology and Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
He AR; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.

Cancers (Basel) ; 14(10)2022 May 23.

Article em En | MEDLINE | ID: mdl-35626165

Palavras-chave

DNA damage repair; PARP inhibitor; biliary tract cancer; homologous recombination repair; synthetic lethality

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article