The Small Molecule GAL-201 Efficiently Detoxifies Soluble Amyloid ß Oligomers: New Approach towards Oral Disease-Modifying Treatment of Alzheimer's Disease.

Russ, Hermann; Mazzanti, Michele; Parsons, Chris; Riemann, Katrin; Gebauer, Alexander; Rammes, Gerhard

Russ, Hermann; Mazzanti, Michele; Parsons, Chris; Riemann, Katrin; Gebauer, Alexander; Rammes, Gerhard.

Afiliação

Russ H; Galimedix Therapeutics Inc., 2704 Calvend Lane, Kensington, MD 20895, USA.
Mazzanti M; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Via Celoria 26, 20133 Milano, Italy.
Parsons C; Galimedix Therapeutics Inc., 2704 Calvend Lane, Kensington, MD 20895, USA.
Riemann K; Department of Anaesthesiology and Intensive Care Medicine, Technical University Munich, Ismaningerstr. 22, 81675 Munich, Germany.
Gebauer A; Galimedix Therapeutics Inc., 2704 Calvend Lane, Kensington, MD 20895, USA.
Rammes G; Department of Anaesthesiology and Intensive Care Medicine, Technical University Munich, Ismaningerstr. 22, 81675 Munich, Germany.

Int J Mol Sci ; 23(10)2022 May 21.

Article em En | MEDLINE | ID: mdl-35628602

Assuntos

Doença de Alzheimer; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Hipocampo/metabolismo; Humanos; Potenciação de Longa Duração; Plasticidade Neuronal; Ratos

Palavras-chave

Alzheimer; GAL-201; LTP; beta amyloid; hippocampus; neurodegenerative disease; slice; soluble oligomers; synaptic plasticity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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