Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(-)-carvone-based conformation-controlling unit.

Suzuki, Yoshiyuki; Moritoki, Keiichi; Kajiwara, Mizuki; Yanagita, Ryo C; Kawanami, Yasuhiro; Hanaki, Yusuke; Irie, Kazuhiro

Suzuki, Yoshiyuki; Moritoki, Keiichi; Kajiwara, Mizuki; Yanagita, Ryo C; Kawanami, Yasuhiro; Hanaki, Yusuke; Irie, Kazuhiro.

Afiliação

Suzuki Y; Division of Applied Biological and Rare Sugar Sciences, Graduate School of Agriculture, Kagawa University, Kagawa, Japan.
Moritoki K; Division of Applied Biological and Rare Sugar Sciences, Graduate School of Agriculture, Kagawa University, Kagawa, Japan.
Kajiwara M; Division of Applied Biological and Rare Sugar Sciences, Graduate School of Agriculture, Kagawa University, Kagawa, Japan.
Yanagita RC; Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Kagawa, Japan.
Kawanami Y; Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Kagawa, Japan.
Hanaki Y; Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Kagawa, Japan.
Irie K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.

Biosci Biotechnol Biochem ; 86(8): 1013-1023, 2022 Jul 22.

Article em En | MEDLINE | ID: mdl-35648459

Assuntos

Antineoplásicos; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Proliferação de Células; Monoterpenos Cicloexânicos; Humanos; Toxinas de Lyngbya; Proteína Quinase C/metabolismo; Relação Estrutura-Atividade

Palavras-chave

antiproliferative activity; aplysiatoxin; cyclic ketal; protein kinase C; simplified analog

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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