A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection.
PLoS Biol
; 20(6): e3001645, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35653351
ABSTRACT
The role that balancing selection plays in the maintenance of genetic diversity remains unresolved. Here, we introduce a new test, based on the McDonald-Kreitman test, in which the number of polymorphisms that are shared between populations is contrasted to those that are private at selected and neutral sites. We show that this simple test is robust to a variety of demographic changes, and that it can also give a direct estimate of the number of shared polymorphisms that are directly maintained by balancing selection. We apply our method to population genomic data from humans and provide some evidence that hundreds of nonsynonymous polymorphisms are subject to balancing selection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
Aminoácidos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article