Neuroprotective Alkamides from the Aerial Parts of Achillea alpina L.
Chem Biodivers
; 19(7): e202200218, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35689671
ABSTRACT
Three new alkamides, achilleamide B-D (1-3) along with five known alkamides (4-8) were isolated from the aerial parts of Achillea alpina L. Structures were elucidated by spectroscopic analysis. Modified Mosher's method and electronic circular dichroism (ECD) calculations were introduced for the absolute configuration of 3. The neuroprotective effects of all the compounds were evaluated by 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, with concentration for 50 % of maximal effect (EC50 ) values of 3.16-24.75â
µM, and the structure-activity relationship was conducted.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fármacos Neuroprotetores
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Achillea
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Neuroblastoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article