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Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia.
Dong, Han; Ham, James Dongjoo; Hu, Guangan; Xie, Guozhu; Vergara, Juliana; Liang, Yong; Ali, Alaa; Tarannum, Mubin; Donner, Hannah; Baginska, Joanna; Abdulhamid, Yasmin; Dinh, Khanhlinh; Soiffer, Robert J; Ritz, Jerome; Glimcher, Laurie H; Chen, Jianzhu; Romee, Rizwan.
Afiliação
  • Dong H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.
  • Ham JD; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02215.
  • Hu G; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Xie G; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Vergara J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Liang Y; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Tarannum M; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Donner H; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Baginska J; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Abdulhamid Y; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Dinh K; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Soiffer RJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Ritz J; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Glimcher LH; Center for Immuno-oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Chen J; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Romee R; Division of Cellular Therapy and Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Proc Natl Acad Sci U S A ; 119(25): e2122379119, 2022 06 21.
Article em En | MEDLINE | ID: mdl-35696582
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Leucemia Mieloide Aguda / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos / Nucleofosmina / Células de Memória Imunológica / Memória Imunológica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Leucemia Mieloide Aguda / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos / Nucleofosmina / Células de Memória Imunológica / Memória Imunológica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article