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Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment.
Wang, Zhongjian; Liu, Wei; Li, Xueyan; Chen, Hongjiao; Qi, Dongying; Pan, Fulu; Liu, Huining; Yu, Shuang; Yi, Bowen; Wang, Guopeng; Liu, Yang.
Afiliação
  • Wang Z; Pharnexcloud Digital Technology Co., Ltd., Chengdu, Sichuan, 610093, China.
  • Liu W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Li X; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Chen H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Qi D; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Pan F; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Liu H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Yu S; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
  • Yi B; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yibowen0229@126.com.
  • Wang G; Zhongcai Health (Beijing) Biological Technology Development Co., Ltd., Beijing, 101500, China. Electronic address: binglelly@163.com.
  • Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: liuyang@bucm.edu.cn.
Regul Toxicol Pharmacol ; 133: 105210, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35700864
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azetidinas / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azetidinas / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article