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Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.
Bustoros, Mark; Anand, Shankara; Sklavenitis-Pistofidis, Romanos; Redd, Robert; Boyle, Eileen M; Zhitomirsky, Benny; Dunford, Andrew J; Tai, Yu-Tzu; Chavda, Selina J; Boehner, Cody; Neuse, Carl Jannes; Rahmat, Mahshid; Dutta, Ankit; Casneuf, Tineke; Verona, Raluca; Kastritis, Efstathis; Trippa, Lorenzo; Stewart, Chip; Walker, Brian A; Davies, Faith E; Dimopoulos, Meletios-Athanasios; Bergsagel, P Leif; Yong, Kwee; Morgan, Gareth J; Aguet, François; Getz, Gad; Ghobrial, Irene M.
Afiliação
  • Bustoros M; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Anand S; Division of Hematology & Medical Oncology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Sklavenitis-Pistofidis R; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
  • Redd R; Boston University School of Medicine, Boston, MA, USA.
  • Boyle EM; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Zhitomirsky B; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
  • Dunford AJ; Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Tai YT; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
  • Chavda SJ; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
  • Boehner C; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
  • Neuse CJ; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Rahmat M; Division of Hematology, University College London, London, UK.
  • Dutta A; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Casneuf T; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Verona R; University of Münster Medical School, Münster, Germany.
  • Kastritis E; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Trippa L; Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA.
  • Stewart C; Janssen Research and Development, Beerse, Belgium.
  • Walker BA; Janssen Research and Development, Spring House, PA, USA.
  • Davies FE; Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
  • Dimopoulos MA; Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bergsagel PL; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
  • Yong K; Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, IN, USA.
  • Morgan GJ; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
  • Aguet F; Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
  • Getz G; Division of Hematology, Mayo Clinic, Scottsdale, AZ, USA.
  • Ghobrial IM; Division of Hematology, University College London, London, UK.
Nat Commun ; 13(1): 3449, 2022 06 15.
Article em En | MEDLINE | ID: mdl-35705541
ABSTRACT
Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogeneity in disease progression. Existing clinical models of progression risk do not fully capture this heterogeneity. Here we integrate 42 genetic alterations from 214 SMM patients using unsupervised binary matrix factorization (BMF) clustering and identify six distinct genetic subtypes. These subtypes are differentially associated with established MM-related RNA signatures, oncogenic and immune transcriptional profiles, and evolving clinical biomarkers. Three genetic subtypes are associated with increased risk of progression to active MM in both the primary and validation cohorts, indicating they can be used to better predict high and low-risk patients within the currently used clinical risk stratification models.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mieloma Múltiplo Latente / Mieloma Múltiplo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mieloma Múltiplo Latente / Mieloma Múltiplo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article