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Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.
Yuan, Li; Zhang, Chunyu; Li, Jiaying; Liao, Yuandong; Huang, Hua; Pan, Yuwen; Du, Qiqiao; Chen, Yili; Wang, Wei; Yao, Shuzhong.
Afiliação
  • Yuan L; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Zhang C; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Li J; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Liao Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Huang H; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Pan Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Du Q; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Chen Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
  • Wang W; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China. Electronic address: wangw245@mail.sysu.edu.cn.
  • Yao S; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China. Electronic address: yaoshuzh@mail.sysu.edu.cn.
Genomics ; 114(4): 110418, 2022 07.
Article em En | MEDLINE | ID: mdl-35724730
Circular RNAs (circRNAs) are a new type of regulatory RNAs, which have been identified to play critical role in various tumors. However, the profiles and roles of circRNAs in cervical cancer (CCa) have not been fully understood and need to be further explored. In the present study, we performed circRNA array and mRNA-sequencing (mRNA-Seq) to profile the differentially expressed circRNAs and mRNAs in CCa tissues. A total of 397 differentially expressed circRNAs and 2138 differentially expressed mRNAs were detected, respectively. Subsequently, a circRNA-miRNA-mRNA regulatory network was constructed and indicated that hsa_circ_0026377 was downregulated in CCa. Overexpression of hsa_circ_0026377 inhibited HeLa and SiHa cells proliferation, migration and invasion. Collectively, this study provided new insights into the circRNA profiles in CCa and suggested that hsa_circ_0026377 might play important roles in CCa development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / MicroRNAs Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / MicroRNAs Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article