Phage-Related Ribosomal Protease (Prp) of <i>Staphylococcus aureus</i>: In Vitro Michaelis-Menten Kinetics, Screening for Inhibitors, and Crystal Structure of a Covalent Inhibition Product Complex.

Hotinger, Julia A; Pendergrass, Heather A; Peterson, Darrell; Wright, H Tonie; May, Aaron E

Phage-Related Ribosomal Protease (Prp) of Staphylococcus aureus: In Vitro Michaelis-Menten Kinetics, Screening for Inhibitors, and Crystal Structure of a Covalent Inhibition Product Complex.

Hotinger, Julia A; Pendergrass, Heather A; Peterson, Darrell; Wright, H Tonie; May, Aaron E.

Afiliação

Hotinger JA; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Pendergrass HA; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Peterson D; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Wright HT; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
May AE; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23298, United States.

Biochemistry ; 61(13): 1323-1336, 2022 07 05.

Article em En | MEDLINE | ID: mdl-35731716

Assuntos

Bacteriófagos; Infecções Estafilocócicas; Bacteriófagos/metabolismo; Endopeptidases/metabolismo; Humanos; Cinética; Peptídeo Hidrolases/metabolismo; Proteínas Ribossômicas/química; Ribossomos/metabolismo; Infecções Estafilocócicas/metabolismo; Staphylococcus aureus/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Bacteriófagos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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