Interception of Nickel Hydride Species and Its Application in Multicomponent Reactions.
Org Lett
; 24(26): 4804-4809, 2022 Jul 08.
Article
em En
| MEDLINE
| ID: mdl-35758604
ABSTRACT
The hydrogen borrowing strategy is an economical method for the α-functionalization of ketones. While this strategy is extremely advantageous, it does not lend itself to the synthesis of ß,ß-disubstituted ketones. This can be achieved, if the in situ generated metal hydride can be intercepted with a nucleophilic coupling partner. We present a multicomponent strategy for the coupling of alcohols, ketones, and boronic acids using only 1 mol % nickel catalyst and without the need for added ligands.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article