Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-&#945;-mediated ERK1/2 and JAK-STAT1 pathways.

Qin, Yi; Cai, Ming-Long; Jin, Hui-Zhi; Huang, Wei; Zhu, Chen; Bozec, Aline; Huang, Jingang; Chen, Zhu

Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways.

Qin, Yi; Cai, Ming-Long; Jin, Hui-Zhi; Huang, Wei; Zhu, Chen; Bozec, Aline; Huang, Jingang; Chen, Zhu.

Afiliação

Qin Y; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Cai ML; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Jin HZ; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Huang W; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhu C; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Bozec A; Department of Internal Medicine III, Institute for Clinical Immunology University of Erlangen-Nuremberg, Erlangen, Germany.
Huang J; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Chen Z; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China doczchen@ustc.edu.cn.

Ann Rheum Dis ; 81(11): 1504-1514, 2022 11.

Article em En | MEDLINE | ID: mdl-35760450

Assuntos

Artrite Experimental; Artrite Reumatoide; Sinoviócitos; Animais; Artrite Experimental/patologia; Linfócitos B; Células Cultivadas; Meios de Cultivo Condicionados; Fibroblastos/metabolismo; Interferons; Interleucina-6/metabolismo; Janus Quinases/metabolismo; Sistema de Sinalização das MAP Quinases; Metaloproteinase 1 da Matriz/metabolismo; Metaloproteinase 13 da Matriz/metabolismo; Metaloproteinase 3 da Matriz/metabolismo; Camundongos; Fator de Transcrição STAT1; Membrana Sinovial/metabolismo; Sinoviócitos/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

B-Lymphocytes; arthritis, rheumatoid; fibroblasts; synovitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Sinoviócitos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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