Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease.

Samant, Neha; Nachum, Gily; Tsepal, Tenzin; Bolon, Daniel N A

Samant, Neha; Nachum, Gily; Tsepal, Tenzin; Bolon, Daniel N A.

Afiliação

Samant N; Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Nachum G; Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Tsepal T; Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Bolon DNA; Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Protein Sci ; 31(7): e4366, 2022 07.

Article em En | MEDLINE | ID: mdl-35762719

Assuntos

Protease de HIV; HIV-1; Aminoácidos/metabolismo; Endopeptidases; Protease de HIV/metabolismo; HIV-1/genética; Peptídeos

Palavras-chave

HIV protease; cut site; fitness landscape; mutational scan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protease de HIV / HIV-1 Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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