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Single-step construction of an acetoxypyrroloindole skeleton via tandem iodocyclization/acetoxylation of indoles.
Kimishima, Atsushi; Kato, Hiroki; Nakaguro, Keijin; Arai, Masayoshi.
Afiliação
  • Kimishima A; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. kimishima_a@phs.osaka-u.ac.jp.
  • Kato H; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. kimishima_a@phs.osaka-u.ac.jp.
  • Nakaguro K; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. kimishima_a@phs.osaka-u.ac.jp.
  • Arai M; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. kimishima_a@phs.osaka-u.ac.jp.
Org Biomol Chem ; 20(27): 5397-5401, 2022 07 13.
Article em En | MEDLINE | ID: mdl-35770620
A method for the synthesis of C3a acetoxy hexahydropyrrolo[2,3-b]indole derivatives via a PhI(OAc)2/nBu4NI mediated tandem iodocyclization/acetoxylation has been developed. The newly developed synthetic strategy features the single-step assembly of various C3a acetoxylated tetrahydropyrrole-, tetrahydrofuran-, and lactone-fused indolines under mild reaction conditions, which enabled efficient asymmetric synthesis of (-)-protubonine B.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esqueleto / Indóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esqueleto / Indóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article