Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.

Krach, Florian; Wheeler, Emily C; Regensburger, Martin; Boerstler, Tom; Wend, Holger; Vu, Anthony Q; Wang, Ruth; Reischl, Stephanie; Boldt, Karsten; Batra, Ranjan; Aigner, Stefan; Ravits, John; Winkler, Juergen; Yeo, Gene W; Winner, Beate

Krach, Florian; Wheeler, Emily C; Regensburger, Martin; Boerstler, Tom; Wend, Holger; Vu, Anthony Q; Wang, Ruth; Reischl, Stephanie; Boldt, Karsten; Batra, Ranjan; Aigner, Stefan; Ravits, John; Winkler, Juergen; Yeo, Gene W; Winner, Beate.

Afiliação

Krach F; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Wheeler EC; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Regensburger M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Boerstler T; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Wend H; Center of Rare Diseases Erlangen (ZSEER), University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Vu AQ; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Wang R; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Reischl S; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Boldt K; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Batra R; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Aigner S; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.
Ravits J; Core Facility for Medical Bioanalytics, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Winkler J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Winner B; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

Acta Neuropathol ; 144(3): 413-435, 2022 09.

Article em En | MEDLINE | ID: mdl-35778567

Assuntos

Esclerose Lateral Amiotrófica; Proteínas de Ligação a DNA; Células-Tronco Pluripotentes Induzidas; Antígeno Neuro-Oncológico Ventral; Processamento Alternativo/genética; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Esclerose Lateral Amiotrófica/patologia; Animais; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Camundongos; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo; Antígeno Neuro-Oncológico Ventral/genética; Antígeno Neuro-Oncológico Ventral/metabolismo; Proteínas Nucleares/genética; Fatores de Processamento de RNA/genética; Fatores de Processamento de RNA/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Proteínas Repressoras/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Células-Tronco Pluripotentes Induzidas / Antígeno Neuro-Oncológico Ventral / Esclerose Lateral Amiotrófica Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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