Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3-hydroxypropionic acid.
Biotechnol Bioeng
; 119(10): 2639-2668, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35781640
ABSTRACT
As an attractive and valuable platform chemical, 3-hydroxypropionic acid (3-HP) can be used to produce a variety of industrially important commodity chemicals and biodegradable polymers. Moreover, the biosynthesis of 3-HP has drawn much attention in recent years due to its sustainability and environmental friendliness. Here, we focus on recent advances, challenges, and metabolic engineering strategies in the biosynthesis of 3-HP. While glucose and glycerol are major carbon sources for its production of 3-HP via microbial fermentation, other carbon sources have also been explored. To increase yield and titer, synthetic biology and metabolic engineering strategies have been explored, including modifying pathway enzymes, eliminating flux blockages due to byproduct synthesis, eliminating toxic byproducts, and optimizing via genome-scale models. This review also provides insights on future directions for 3-HP biosynthesis.
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01-internacional
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MEDLINE
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Ácido Láctico
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Engenharia Metabólica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article