Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.

Wu, Chih-Cheng; Chang, Cheng-Yi; Tzeng, Chung-Yuh; Huang, Jen-Hsuan; Hung, Chih-Jen; Chen, Wen-Ying; Liao, Su-Lan; Kuan, Yu-Hsiang; Chen, Chun-Jung

Wu, Chih-Cheng; Chang, Cheng-Yi; Tzeng, Chung-Yuh; Huang, Jen-Hsuan; Hung, Chih-Jen; Chen, Wen-Ying; Liao, Su-Lan; Kuan, Yu-Hsiang; Chen, Chun-Jung.

Afiliação

Wu CC; Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
Chang CY; Department of Financial Engineering, Providence University, Taichung City 433, Taiwan.
Tzeng CY; Department of Data Science and Big Data Analytics, Providence University, Taichung City 433, Taiwan.
Huang JH; Department of Surgery, Feng Yuan Hospital, Taichung City 420, Taiwan.
Hung CJ; Department of Veterinary Medicine, National Chung-Hsing University, Taichung City 402, Taiwan.
Chen WY; Department of Orthopedics, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
Liao SL; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua County 515, Taiwan.
Kuan YH; Department of Anesthesiology, Show Chwan Memorial Hospital, Changhua County 500, Taiwan.
Chen CJ; Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, Taiwan.

Int J Mol Sci ; 23(13)2022 Jun 28.

Article em En | MEDLINE | ID: mdl-35806200

Assuntos

Lesões por Esmagamento; Proteína HMGB1; Neuralgia; Traumatismos dos Nervos Periféricos; Neuropatia Ciática; Animais; Bupivacaína/farmacologia; Constrição; Lesões por Esmagamento/metabolismo; Citocinas/metabolismo; Proteína HMGB1/metabolismo; Hiperalgesia/tratamento farmacológico; Hiperalgesia/metabolismo; Injeções Espinhais; Fatores Reguladores de Interferon/metabolismo; Microglia/metabolismo; NF-kappa B/metabolismo; Neuralgia/tratamento farmacológico; Neuralgia/etiologia; Neuralgia/metabolismo; Traumatismos dos Nervos Periféricos/metabolismo; Ratos; Ratos Sprague-Dawley; Nervo Isquiático/metabolismo; Neuropatia Ciática/metabolismo; Medula Espinal/metabolismo; Receptor 4 Toll-Like/metabolismo

Palavras-chave

anesthetics; microglia; neuropathic pain; sciatic nerve

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuropatia Ciática / Proteína HMGB1 / Traumatismos dos Nervos Periféricos / Lesões por Esmagamento / Neuralgia Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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