PTEN/AKT signaling pathway related to hTERT downregulation and telomere shortening induced in Toxoplasma GRA16-expressing colorectal cancer cells.

Seo, Seung-Hwan; Shin, Ji-Hun; Ham, Do-Won; Shin, Eun-Hee

Seo, Seung-Hwan; Shin, Ji-Hun; Ham, Do-Won; Shin, Eun-Hee.

Afiliação

Seo SH; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Republic of Korea.
Shin JH; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Republic of Korea.
Ham DW; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Republic of Korea.
Shin EH; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Republic of Korea; Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea. Electronic address: ehshin@snu.ac.kr.

Biomed Pharmacother ; 153: 113366, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35810694

Assuntos

Neoplasias Colorretais; Telomerase; Toxoplasma; Neoplasias Colorretais/genética; Regulação para Baixo/genética; Humanos; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Proteína Fosfatase 2/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Telomerase/metabolismo; Telômero/genética; Telômero/metabolismo; Encurtamento do Telômero

Palavras-chave

Colorectal cancer cell; GRA16; HTERT; P-AKT(S473); Telomere shortening; Toxoplasma gondii

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasma / Neoplasias Colorretais / Telomerase Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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