Surface Mobility of Amorphous Indomethacin Containing Moisture and a Surfactant: A Concentration-Temperature Superposition Principle.
Mol Pharm
; 19(8): 2962-2970, 2022 08 01.
Article
em En
| MEDLINE
| ID: mdl-35816108
ABSTRACT
An amorphous material can have vastly higher mobility on the surface than in the bulk and, as a result, shows fast surface crystallization. Most amorphous materials contain multiple components, but the effect of composition on surface dynamics remains poorly understood. In this study, the surface mobility of amorphous indomethacin was measured using the method of surface-grating decay in the presence of moisture and the surfactant Tween 20. It is found that both components significantly enhance the surface mobility, and their effects are well described by the principle of concentration-temperature superposition (CTS); that is, the same surface dynamics is observed at the same Tg-normalized temperature T/Tg, where Tg is the composition-dependent glass transition temperature. For doped indomethacin showing CTS, the mechanism of surface evolution for a 1000 nm wavelength surface grating transitions from viscous flow at high temperatures to surface diffusion at low temperatures at 1.04 Tg. For the surfactant-doped system, the Tg used is the value for the surface layer that reflects the surface enrichment of the surfactant (measured by X-ray photoelectron spectroscopy). At a high surfactant concentration (>10% by weight), the surface-grating decay rate in the surface-diffusion regime is limited by the large, slow-diffusing surfactant molecules; in this case, CTS holds only for the viscous-flow regime. The CTS principle allows the prediction of the surface dynamics of multicomponent amorphous materials.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
Indometacina
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article