High-throughput profiling of antibody self-association in multiple formulation conditions by PEG stabilized self-interaction nanoparticle spectroscopy.

Phan, Samantha; Walmer, Auralee; Shaw, Eudean W; Chai, Qing

Phan, Samantha; Walmer, Auralee; Shaw, Eudean W; Chai, Qing.

Afiliação

Phan S; Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Biotechnology Center, San Diego, CA, USA.
Walmer A; Research Information & Digital Solutions, Lilly Biotechnology Center, San Diego, CA, USA.
Shaw EW; Research Information & Digital Solutions, Lilly Biotechnology Center, San Diego, CA, USA.
Chai Q; Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Biotechnology Center, San Diego, CA, USA.

MAbs ; 14(1): 2094750, 2022.

Article em En | MEDLINE | ID: mdl-35830420

Assuntos

Anticorpos Monoclonais; Nanopartículas; Anticorpos Monoclonais/química; Nanopartículas/química; Análise Espectral

Palavras-chave

Antibodies; PEG2000-stabilized self-interaction nanoparticle spectroscopy (PS-SINS); affinity-capture self-interaction nanoparticle spectroscopy (AC-SINS); antibody-gold conjugates; colloidal stability; developability; formulation; viscosity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Anticorpos Monoclonais Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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