IOX1 Fails to Reduce &#945;-Globin and Mediates Î³-Globin Silencing in Adult ß<sup>0</sup>-Thalassemia/Hemoglobin E Erythroid Progenitor Cells.

Khamphikham, Pinyaphat; Wongborisuth, Chokdee; Pornprasert, Sakorn; Tantiworawit, Adisak; Tangprasittipap, Amornrat; Songdej, Duantida; Hongeng, Suradej

IOX1 Fails to Reduce α-Globin and Mediates Î³-Globin Silencing in Adult ß⁰-Thalassemia/Hemoglobin E Erythroid Progenitor Cells.

Khamphikham, Pinyaphat; Wongborisuth, Chokdee; Pornprasert, Sakorn; Tantiworawit, Adisak; Tangprasittipap, Amornrat; Songdej, Duantida; Hongeng, Suradej.

Afiliação

Khamphikham P; Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Electronic address: pinyaphat.kha@cmu.ac.th.
Wongborisuth C; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pornprasert S; Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Tantiworawit A; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Tangprasittipap A; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Songdej D; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Hongeng S; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: suradej.hon@mahidol.ac.th.

Exp Hematol ; 112-113: 9-14.e7, 2022.

Article em En | MEDLINE | ID: mdl-35839944

Assuntos

Hemoglobina E; Talassemia; Talassemia beta; Adulto; Proteínas de Transporte/metabolismo; Células Eritroides/metabolismo; Células Precursoras Eritroides/metabolismo; Hemoglobina Fetal; Hemoglobina E/genética; Hemoglobina E/metabolismo; Humanos; Hipóxia/metabolismo; RNA Mensageiro/genética; Talassemia/metabolismo; alfa-Globinas/metabolismo; Talassemia beta/terapia; gama-Globinas/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia / Hemoglobina E / Talassemia beta Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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